Columbia Global Centers | Mumbai, 12-13, Maker Chambers VI, First floor, Jamnalal Bajaj Road, Nariman Point, Mumbai 400 021
Columbia Global Centers | Mumbai invites you for its annual Yusuf Hamied Distinguished Lecture on March 4, 2019, by Gary Miller, Vice Dean for Research Strategy and Innovation, Mailman School of Public Health at Columbia University.
Derived from the term exposure, the exposome is an -omic scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of resolution. Emerging technologies make it possible to obtain detailed information on drugs, toxicants, pollutants, nutrients, and physical and psychological stressors on an -omic scale. These forces can also be assessed at systems and network levels, providing a framework for advances in human health. The exposome paradigm can improve the analysis of drug interactions and detection of adverse effects of drugs and toxicants and provide data on biological responses to exposures. The comprehensive model can provide data at the individual level for precision medicine, group level for clinical trials, and population level for public health. Dr. Miller led the first center on the exposome in the U.S. and wrote the first book on the topic. He moved to Columbia in 2018 to lead an effort to advance exposome science.
Note: Seats are limited to relevant individuals.
About the speaker:
Dr. Gary Miller is the Vice Dean for Research Strategy and Innovation and Professor of Environmental Health Sciences at the Mailman School of Public Health, Columbia University. He was the founding director of the HERCULES Exposome Research Center at Emory University, the first exposome-based research center in the U.S. He authored the first book on the topic, The Exposome: A Primer, published by Elsevier. His research focuses on environmental drivers of neurodegeneration. His laboratory uses a variety of methods including transgenic mouse production, immunohistochemistry, neurotransmitter transport assays, high-resolution metabolomics, electrochemistry, and behavioral assays. His work is conducted in several experimental models from cultured neurons and C. elegans to mice and human studies. He is an advisor to several exposome-associated research entities, including the Human Biomonitoring for the European Union (HBM4EU). He also serves as Editor-in-Chief of Toxicological Sciences, the official journal of the Society of Toxicology.
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