Logical Reasoning in Human Genetics Lecture 9 - Genetics Modifiers in High-Risk Cohorts

The ninth Lecture of the "Logical Reasoning in Human Genetics" course discussed why and how we study cohorts of high-risk individuals to better understand a complex aging trait, Alzheimer’s Disease (AD).

 

December 09, 2021

In partnership with Institut Pasteur Tunis, CGC Tunis will hosted Pr. Joseph H. Lee, Professor of Epidemiology at the Columbia University Medical Center, Columbia University, along with a team of prominent geneticists to examine the Genetics Modifiers in High-Risk Cohorts.

The ninth Lecture of the "Logical Reasoning in Human Genetics" course discussed why and how we study cohorts of high-risk individuals to better understand a complex aging trait, Alzheimer’s Disease (AD).
Specifically, we questioned how individuals who carry known genetic risk factors for AD (namely PSEN1 and APP) manage to escape (or delay their age at the onset of) AD and focused on two studies of high-risk cohorts:

. Carrier families of the founder PSEN1-G206A mutation in Puerto Rico
. Individuals with Down Syndrome.

We were also pleased to have among us:

Pr. Joseph Terwilliger, professor at the Department of Genetics and Development, Columbia University

Pr. Ryan Hernandez, Associate Professor, Bioengineering School of Pharmacy, University of California, San Francisco.

Pr. Ghada Elkameh, Professor of Clinical Genetics, Coordinator of the Hereditary Blood Disorders and Genodermatoses Clinics and Research Teams, Human Genetics and Genome Research Division, National Research Centre

Dr. Sonia Abdelhak, Principal Biologist, Head of Research Unit, Institut Pasteur de Tunis.

Dr. Yosr Hamdi, Assistant Biologist at the Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis.

Dr. Harald H. Göring., Bennett Dyke & Jean MacCluer Endowed Professor, the South Texas Diabetes and Obesity Institute & Department of Human Genetics, School of Medicine, San Antonio, Texas.

Dr. Markus Perola, Research Professor at the National Institute for Health and Welfare (THL), Helsinki, Finland.