Dr. Guo was born and grew up in China. He received his B.S. in applied mechanics from Peking University. He continued his graduate studies in the US and received his M.S. in 1990 and Ph.D. in 1994 in Medical Engineering and Medical Physics from Harvard University-MIT. From 1994 to 1996, Professor Guo did his postdoctoral fellowship in the Orthopaedic Research Laboratories at the University of Michigan at Ann Arbor. In 1996, he joined the Department of Mechanical Engineering and Biomedical Engineering at Columbia University as an Assistant Professor. He was promoted to Associate Professor with tenure in 2003, Professor in 2007, and named Stanley Dicker Professor in 2018. He directs the Bone Bioengineering Laboratory in the Department of Biomedical Engineering at Columbia, focusing his research interests on micromechanics of bone tissue, computational biomechanics, and mechanobiology of bone. His past honors include the Young Investigator Recognition Award from the Orthopaedic Research Society, the National Research Service Award from the US National Institutes of Health (NIH), a CAREER award from the US National Foundation of Science (NSF), Funds for Talented Professionals (Joint Research Fund for Overseas Chinese Young Scholars) from the National Natural Science Foundation of China, and Christopher R Jacobs Award from Biomedical Engineering Society (BMES). He is elected fellow of the American Institute for Medical and Biological Engineering, American Society of Mechanical Engineers, BMES, American Society of Bone and Mineral Research, International Combined Orthopaedic Research Societies, and International Academy of Medical and Biological Engineering. He was one of the founders and co-editor-in-chief of Cellular and Molecular Bioengineering (CMBE), an international journal of BMES. He has served on many NIH, NSF, and NASA review panels. The Whitaker Foundation, the NSF, and the NIH have supported his research. He served as President of the International Chinese Musculoskeletal Research Society, the Society for Physical Regulation in Biology and Medicine, a Member of the Board of Directors of the Orthopaedic Research Society, and a Member of the Board of Directors of AIMBE. He founded the Special Interest Group (SIG) in CMBE at the BMES and served as its founding Chair. He served as the Chair of the Department of Biomedical Engineering at Columbia University from 2017 to 2023, and he founded the Northeast BME League and served as its inaugural President.