Griffith-Jones specializes in researching and providing policy advice on capital flows; macro-economic management of capital flows in developing and transition countries and reform of international financial architecture from a development perspective. She worked as an economist at Chile’s Central Bank in the 1970s, and at the Economic Commission for Latin America and the Caribbean (ECLAC) in the 1990s. She has worked as a consultant for many international organizations such as the Inter-American Development Bank (IDB), UNICEF and the UN Development Program (UNDP), as well as for central banks and governments such as Brazil, Chile, Sweden and the United Kingdom. Lately Griffith-Jones has served as an economic advisor to Chilean president-elect Gabriel Boric.
She has published widely on the international financial system and its reform.